PTEN(Phospho Ser370) Polyclonal Antibody, 100ul Serological Pipets The N-terminal domain of this

The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex

which in turn plays a role in myelination

This gene is disrupted in a t(1

This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs)

MIM 300172)

PTEN(Phospho Ser370) Polyclonal Antibody, 100ul Serological Pipets The N-terminal domain of thisThis gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide